CROI 2026 - CROI 2026

Workshop: Scott M. Hammer Workshop for New Researchers and Trainees

"Welcome and Session Overview for the Scott M. Hammer Workshop for New Researchers and Trainees" by

Workshop: Scott M. Hammer Workshop for New Researchers and Trainees

"What Has the Advent of Capsid Inhibitors Taught Us About HIV Pathogenesis: Navigating Virology Presentations at CROI 2026" by Stuart J. D. Neil King's College London, London, UK

Workshop: Scott M. Hammer Workshop for New Researchers and Trainees

"Immunology of HIV Cure and Beyond: Navigating Immunology Presentations at CROI 2026" by John Frater University of Oxford, Oxford, UK

Workshop: Scott M. Hammer Workshop for New Researchers and Trainees

"Long-Acting HIV Treatment Regimens: Where Are We and Where Are We Going? Navigating HIV Treatment Presentations at CROI 2026" by Ruanne V. Barnabas Massachusetts General Hospital, Boston, MA, USA

Workshop: Scott M. Hammer Workshop for New Researchers and Trainees

"Taking Prevention to the Population Level: Navigating Implementation Science Presentations at CROI 2026" by Renee Heffron University of Alabama at Birmingham, Birmingham, AL, USA

Workshop: Scott M. Hammer Workshop for New Researchers and Trainees

"Reclaiming the Narrative: Navigating Research Through Turbulent Times" by Sunil S. Solomon The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Workshop: Scott M. Hammer Workshop for New Researchers and Trainees

"Community Perspectives Video" by

Workshop: Clinical Trial Design and Analysis Workshop

"Clinical Trials in the Post-Lenacapavir Era" by David V. Glidden University of California San Francisco, San Francisco, CA, USA

Workshop: Clinical Trial Design and Analysis Workshop

"Measurement of Outcomes in Health Care Delivery: Implementation Trials" by Thomas A. Odeny Washington University, St Louis, MO, USA

Workshop: Clinical Trial Design and Analysis Workshop

"Accounting for User Choice: Preference Trials in HIV Prevention and Treatment Research" by Elizabeth R. Brown Fred Hutchinson Cancer Center, Seattle, WA, USA

Workshop: Contemporary Issues in Clinical Management: A Case-Based Workshop

"Case Presentation With Panel Discussion, Plus Questions and Answers From the Audience" by Sanjay Bhagani Royal Free London NHS Foundation Trust, London, UK

Brenda E. Crabtree-Ramírez Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

Andrew D. Kambugu Infectious Disease Institute, Kampala, Uganda

Susanna Naggie Durham VA Health Care System, Durham, NC, USA

Workshop: Frontiers in Laboratory Sciences

"Leveraging Artificial Intelligence for Spatial Analysis of Infectious Diseases" by Jacob D. Estes Oregon Health & Science University, Portland, OR, USA

Workshop: Frontiers in Laboratory Sciences

"Spatial Transcriptomic and Proteomic Profiling of HIV in Tissues" by Zaza Ndhlovu Africa Health Research Institute, Mtubatuba, South Africa

Workshop: Frontiers in Laboratory Sciences

"Integrative Structural and Computational Approaches to RNA Biology" by Megan Ken The Scripps Research Institute, La Jolla, CA, USA

Workshop: Frontiers in Laboratory Sciences

"Latent HIV Reversal via Functional Genomics and Single-Cell Perturbation Modeling" by Wei Li University of Maryland, Baltimore, MD, USA

Opening Session

"Welcome From the Conference Chair" by Nicolas Chomont Université de Montréal, Montreal, Canada

Opening Session

"Introduction to the Lifetime Achievement Award" by Constance A. Benson University of California San Diego, La Jolla, CA, USA

Opening Session

"Acceptance of the Lifetime Achievement Award" by Carl W. Dieffenbach Fogarty International Center, National Institutes of Health, Bethesda, MD, USA

Opening Session

"Introduction to the Bernard Fields Lecture" by Nicolas Chomont Université de Montréal, Montreal, Canada

Opening Session

"Unfinished Business: Thirty Years of Persistence, Progress, and Partnerships in HIV Cure Science" by Sharon R. Lewin The University of Melbourne, Melbourne, Australia

Opening Session

"Introduction to the Martin Delaney Presentation" by Michael Louella UW/Fred Hutch Center for AIDS Research (CFAR), Seattle, WA, USA

Opening Session

"''Annus Horribilis" and The War on Science: Thoughts on Resisting and Rebuilding" by Peter Staley PrEP4All, New York, NY, USA

Opening Session

"Introduction to the N'Galy-Mann Lecture" by Wafaa M. El-Sadr Columbia University, New York, NY, USA

Opening Session

"The ART of Prevention: People, Science, Progress" by Linda-Gail Bekker Desmond Tutu HIV Foundation, Cape Town, South Africa

Opening Session

"Conclusion of the Opening Session and Welcome to the Opening Reception" by Peter W. Hunt University of California San Francisco, San Francisco, CA, USA

Monday Plenary Session

"CROI Program Committee Chair Welcome to Monday" by Peter W. Hunt University of California San Francisco, San Francisco, CA, USA

Monday Plenary Session

"Meeting the Moment: HIV Treatment and Prevention" by Ilesh Jani Mozambique National Institute of Health, Maputo, Mozambique

Monday Plenary Session

"Structure, Function, and Inhibition of the HIV Capsid" by Wesley I. Sundquist University of Utah, Salt Lake City, UT, USA

Oral Abstract: Beyond the Virus: The Expanding Landscape of HIV-Associated Conditions

"Increased Risk of Heart Failure With Preserved Ejection Fraction in South Africans With HIV" by Zaayid Omar University of Cape Town, Cape Town, South Africa

Oral Abstract: Beyond the Virus: The Expanding Landscape of HIV-Associated Conditions

"Relationship of Inflammatory, Cardiac, and Lipid Biomarkers to Cardiovascular Events in REPRIEVE" by Steven Grinspoon Massachusetts General Hospital, Boston, MA, USA

Oral Abstract: Beyond the Virus: The Expanding Landscape of HIV-Associated Conditions

"Incident Hypertension in REPRIEVE: Risk Factors, Pitavastatin Effect & Cardiovascular Consequences" by Esteban Martinez Hospital Clinic of Barcelona, Barcelona, Spain

Oral Abstract: Beyond the Virus: The Expanding Landscape of HIV-Associated Conditions

"Population-Level Obesity Trends by HIV Status in Pre-/Post-DTG Era in Rural East Africa SEARCH Study" by Elijah R. Kakande Infectious Disease Research Collaboration, Kampala, Uganda

Oral Abstract: Beyond the Virus: The Expanding Landscape of HIV-Associated Conditions

"Questions and Answers (Part 1)" by

Oral Abstract: Beyond the Virus: The Expanding Landscape of HIV-Associated Conditions

"Weight Rebound After Discontinuing Metformin in PWH Without Diabetes: Week 144 Trial Results" by Cristina Marcelo Calvo La Paz University Hospital, Madrid, Spain

Oral Abstract: Beyond the Virus: The Expanding Landscape of HIV-Associated Conditions

"Rates and Risk Factors for Oropharyngeal Squamous Cell Carcinoma Among People Living With HIV" by Antonio Bandala-Jacques The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

Oral Abstract: Beyond the Virus: The Expanding Landscape of HIV-Associated Conditions

"Kaposi Sarcoma Herpesvirus in Plasma: Association With Treatment Failure in Limited-Stage AIDS-KS" by Dirk P. Dittmer University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Oral Abstract: Beyond the Virus: The Expanding Landscape of HIV-Associated Conditions

"Intensification of Tuberculosis Treatment in Severely Immunocompromised Individuals With HIV" by François-Xavier Blanc University Hospital of Nantes, Nantes, France

Oral Abstract: Beyond the Virus: The Expanding Landscape of HIV-Associated Conditions

"Adjunctive Prednisone for Inpatients With Disseminated HIV-Associated TB" by Phiona E. Namale University of Cape Town, Cape Town, South Africa

Oral Abstract: Beyond the Virus: The Expanding Landscape of HIV-Associated Conditions

"Questions and Answers (Part 2)" by

Oral Abstract: From Breakthroughs to Backbones: The Evolving Landscape of HIV PrEP

"Introduction of Speakers (Part 1)" by

Oral Abstract: From Breakthroughs to Backbones: The Evolving Landscape of HIV PrEP

"Implants Releasing NRTTI MK-8591 Fail to Protect Macaques Against SHIV Containing the M184V Mutation" by Charles Dobard Centers for Disease Control and Prevention, Atlanta, GA, USA

Oral Abstract: From Breakthroughs to Backbones: The Evolving Landscape of HIV PrEP

"MK-8527 Phase III Dose Selection for Monthly Oral HIV-1 Preexposure Prophylaxis" by Yash Kapoor Merck Sharp & Dohme, Rahway, NJ, USA

Oral Abstract: From Breakthroughs to Backbones: The Evolving Landscape of HIV PrEP

"Final Results of the ANRS PREVENIR Study With Daily or On-Demand Oral PrEP With TDF/FTC in Paris" by Jean-Michel Molina Assistance Publique – Hôpitaux de Paris, Paris, France

Oral Abstract: From Breakthroughs to Backbones: The Evolving Landscape of HIV PrEP

"Twice-Yearly Subcutaneous Lenacapavir for PrEP: Updated HIV-1 Incidence and Safety Data in PURPOSE 1" by Nkosiphile Ndlovu Wits Reproductive Health and HIV Institute, Johannesburg, South Africa

Oral Abstract: From Breakthroughs to Backbones: The Evolving Landscape of HIV PrEP

"Questions and Answers (Part 1)" by

Oral Abstract: From Breakthroughs to Backbones: The Evolving Landscape of HIV PrEP

"Lenacapavir for PrEP: HIV-1 Incidence and Safety From PURPOSE 2 at End of Randomized Blinded Phase" by Valeria D. Cantos Lucio Emory University, Atlanta, GA, USA

Oral Abstract: From Breakthroughs to Backbones: The Evolving Landscape of HIV PrEP

"Resistance Analyses of the PURPOSE Studies Through the End of the Randomized Blinded Phase" by Stephanie Cox Gilead Sciences, Inc, Foster City, CA, USA

Oral Abstract: From Breakthroughs to Backbones: The Evolving Landscape of HIV PrEP

"RCT of Dynamic Choice to Provide Oral PrEP to Postpartum South African Women" by Dvora L. Joseph Davey University of California Los Angeles, Los Angeles, CA, USA

Oral Abstract: From Breakthroughs to Backbones: The Evolving Landscape of HIV PrEP

"Effect of Different Pharmacy PrEP Delivery Models on Initiation and Continuation in Kenya: A cRCT" by Katrina F. Ortblad Fred Hutchinson Cancer Center, Seattle, WA, USA

Oral Abstract: From Breakthroughs to Backbones: The Evolving Landscape of HIV PrEP

"Questions and Answers (Part 2)" by

Oral Abstract: Frontiers in Neuropathogenesis and Tissue Biology: Decoded Through Cellular Dynamics, Metabolics, and Imaging

"Impact of Elevated S100A8/A9 and Classical Monocytes on Cerebrovascular Dysfunction in Long COVID" by Meera V. Singh University of Rochester Medical Center, Rochester, NY, USA

Oral Abstract: Frontiers in Neuropathogenesis and Tissue Biology: Decoded Through Cellular Dynamics, Metabolics, and Imaging

"Shared Microglia Subtypes in Brain and CSF Reveal HIV-Driven Immune Dysregulation" by Paraskevas Filippidis Yale University, New Haven, CT, USA

Oral Abstract: Frontiers in Neuropathogenesis and Tissue Biology: Decoded Through Cellular Dynamics, Metabolics, and Imaging

"Characterization of HIV Proviruses in Brain Microglia in PWH on ART" by Alana N. Thomas National Cancer Institute at Frederick, Frederick, MD, USA

Oral Abstract: Frontiers in Neuropathogenesis and Tissue Biology: Decoded Through Cellular Dynamics, Metabolics, and Imaging

"Tryptophan Metabolomic Profiling in Persons With and Without HIV: Associations With CNS Outcomes" by Alan Winston Imperial College London, London, UK

Oral Abstract: Frontiers in Neuropathogenesis and Tissue Biology: Decoded Through Cellular Dynamics, Metabolics, and Imaging

"Questions and Answers (Part 1)" by

Oral Abstract: Frontiers in Neuropathogenesis and Tissue Biology: Decoded Through Cellular Dynamics, Metabolics, and Imaging

"Introduction of Speakers (Part 2)" by

Oral Abstract: Frontiers in Neuropathogenesis and Tissue Biology: Decoded Through Cellular Dynamics, Metabolics, and Imaging

"Effects of Low-Dose Hydrocortisone on Cognition in Women With HIV: A Placebo-Controlled Trial" by Leah Rubin The John Hopkins University, Baltimore, MD, USA

Oral Abstract: Frontiers in Neuropathogenesis and Tissue Biology: Decoded Through Cellular Dynamics, Metabolics, and Imaging

"Multimodal PET Imaging Reveals Focal HIV Activity and Immune Activation During ATI Prior to Rebound" by Timothy J. Henrich University of California San Francisco, San Francisco, CA, USA

Oral Abstract: Frontiers in Neuropathogenesis and Tissue Biology: Decoded Through Cellular Dynamics, Metabolics, and Imaging

"Targeting Mucosal Immunity Through Fc-Engineered Broadly Neutralizing Antibodies" by Claudia Stroupe Northwestern University, Chicago, IL, USA

Oral Abstract: Frontiers in Neuropathogenesis and Tissue Biology: Decoded Through Cellular Dynamics, Metabolics, and Imaging

"GLP-1 RA Induces Gut T-Cell and Epithelial Remodeling in PWH From a Clinical Trial in South Africa" by Miguel Marin Africa Health Research Institute, Durban, South Africa

Oral Abstract: Frontiers in Neuropathogenesis and Tissue Biology: Decoded Through Cellular Dynamics, Metabolics, and Imaging

"Questions and Answers (Part 2)" by

Oral Abstract: Interaction of HIV With Cells and People

"Structural and Mechanistic Bases for Encapsulation of Ribonucleoprotein Complexes Inside HIV-1 Cores" by Mamuka Kvaratskhelia University of Colorado Anschutz Medical Campus, Aurora, CO, USA

Oral Abstract: Interaction of HIV With Cells and People

"Molecular and Structural Determinants of MDA5 Sensing of HIV-1 Unspliced RNA" by Hisashi Akiyama Boston University, Boston, MA, USA

Oral Abstract: Interaction of HIV With Cells and People

"RNA m6A Modification Confers HIV Replication Fitness and Resistance to Type-I Interferon" by Jonathan Karn Case Western Reserve University, Cleveland, OH, USA

Oral Abstract: Interaction of HIV With Cells and People

"Species-Specific APOBEC3G mRNA Splicing Drives Divergent HIV Versus SIV Hypermutation Landscapes" by Armando D. Mendez Texas Biomedical Research Institute, San Antonio, TX, USA

Oral Abstract: Interaction of HIV With Cells and People

"Questions and Answers (Part 1)" by

Oral Abstract: Interaction of HIV With Cells and People

"Genome-Wide HIV-Guided CRISPR Screen Identifies Novel Antiviral Factors Including Targets of Vpu" by Guillermo Gosálbez Ulm University Medical Center, Ulm, Germany

Oral Abstract: Interaction of HIV With Cells and People

"Systematic Discovery of Pro- and Anti-HIV Host Factors in Primary Human CD4+ T Cells" by Eli Dugan University of California San Francisco, San Francisco, CA, USA

Oral Abstract: Interaction of HIV With Cells and People

"Defective HIV-1 Proviruses Express Env and Contribute to Soluble gp120 in the Plasma of PWH on ART" by Mehdi Benlarbi Université de Montréal, Montreal, Canada

Oral Abstract: Interaction of HIV With Cells and People

"Sex-Specific Differences in HIV Replication and Inflammation in the Rectal Explant Challenge Model" by Stacey A. Smith Emory University, Atlanta, GA, USA

Oral Abstract: Interaction of HIV With Cells and People

"Questions and Answers (Part 2)" by

Themed Discussion: Mechanisms and Modifiers: Treatable Causes of Cognitive Impairment and Depression

"Session Overview" by Leah H. Rubin The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Themed Discussion: Mechanisms and Modifiers: Treatable Causes of Cognitive Impairment and Depression

"MASH and the Progression of Cognitive Decline in Older People With HIV: A Prospective Study" by Katekarn Porkaew Chulalongkorn University, Bangkok, Thailand

Themed Discussion: Mechanisms and Modifiers: Treatable Causes of Cognitive Impairment and Depression

"Metabolic Syndrome and Cognitive Impairment Among Men With and Without HIV" by Sara M. Hockney Northwestern University, Chicago, IL, USA

Themed Discussion: Mechanisms and Modifiers: Treatable Causes of Cognitive Impairment and Depression

"Modifiable Factors Could Mitigate Greater Burden of Brain Small Vessel Injury in Female Individuals" by Elana Farrell University of California San Francisco, San Francisco, CA, USA

Themed Discussion: Mechanisms and Modifiers: Treatable Causes of Cognitive Impairment and Depression

"The Impact of Semaglutide on Depressive Symptoms Among People With HIV" by Lara Haidar University of Manitoba, Winnipeg, Canada

Themed Discussion: Mechanisms and Modifiers: Treatable Causes of Cognitive Impairment and Depression

"Discussion With Audience Questions and Answers" by

Themed Discussion: New Host Factors: Regulating Nuclear Events of HIV Replication

"Session Overview" by Edward Campbell Loyola University Chicago, Chicago, IL, USA

Themed Discussion: New Host Factors: Regulating Nuclear Events of HIV Replication

"BLM Helicase Is Required for Efficient HIV Infection in Macrophages" by Andrew Leal Boston University, Boston, MA, USA

Themed Discussion: New Host Factors: Regulating Nuclear Events of HIV Replication

"CD46 Interacts With Sp1 to Control HIV Expression in Infected T Cells" by Pavitra Ramdas National Institute of Allergy and Infectious Diseases, Baltimore, MD, USA

Themed Discussion: New Host Factors: Regulating Nuclear Events of HIV Replication

"Exploring the Role of FUBP1 in HIV Replication and Latency" by Fiona Carter-Tod Northwestern University, Chicago, IL, USA

Themed Discussion: New Host Factors: Regulating Nuclear Events of HIV Replication

"Cis- and Trans-Acting Factors That Mediate Nuclear Retention of Intron-Containing HIV-1 Transcripts" by Anthony Boateng Washington University in St Louis, St Louis, MO, USA

Themed Discussion: New Host Factors: Regulating Nuclear Events of HIV Replication

"Discussion With Audience Questions and Answers" by

Themed Discussion: Noncanonical Mutations Conferring Resistance to InSTIs

"Session Overview" by Daniel R. Kuritzkes Harvard Medical School, Boston, MA, USA

Themed Discussion: Noncanonical Mutations Conferring Resistance to InSTIs

"Env Mutations Are a Gateway for Acquisition of InSTI Resistance" by Yuta Hikichi National Cancer Institute at Frederick, Frederick, MD, USA

Themed Discussion: Noncanonical Mutations Conferring Resistance to InSTIs

"Nucleocapsid Mutations During Virologic Failure of an Integrase Inhibitor-Based Regimen" by Charlotte Charpentier Assistance Publique – Hôpitaux de Paris, Paris, France

Themed Discussion: Noncanonical Mutations Conferring Resistance to InSTIs

"Noncanonical Resistance Mutations in TLD-Treated Individuals With Unexplained Virologic Failure" by Nicola Coetzee Stellenbosch University, Cape Town, South Africa

Themed Discussion: Noncanonical Mutations Conferring Resistance to InSTIs

"Characterization of Mutations Outside the Integrase in HIV-1 Individuals in Whom Dolutegravir Failed" by Aurelie Minelle Kengni Ngueko Centre International de Référence Chantal Biya, Yaoundé, Cameroon

Themed Discussion: Noncanonical Mutations Conferring Resistance to InSTIs

"Discussion With Audience Questions and Answers" by

Themed Discussion: Sleepless in Denver: Impact of Funding Changes on HIV Care

"Session Overview" by Jennifer Kates Kaiser Family Foundation, Washington, DC, USA

Themed Discussion: Sleepless in Denver: Impact of Funding Changes on HIV Care

"Impact of US Funding Shifts on HIV Care: A Rapid Survey of Clinics and Programs in 32 Countries" by Ellen Brazier Institute for Implementation Science in Population Health, New York, NY, USA

Themed Discussion: Sleepless in Denver: Impact of Funding Changes on HIV Care

"Population-Representative Consequences of Foreign Aid Instability for HIV Services in South Africa" by Lindsey Filiatreau Washington University in St Louis, St Louis, MO, USA

Themed Discussion: Sleepless in Denver: Impact of Funding Changes on HIV Care

"Short-Term Poverty Relief and ART Adherence: Insights From a Natural Experiment of SNAP Recipients" by Aaron Richterman University of Pennsylvania, Philadelphia, PA, USA

Themed Discussion: Sleepless in Denver: Impact of Funding Changes on HIV Care

"Discussion With Audience Questions and Answers" by

Science Spotlight: Funding and Cost-Effectiveness

"US National and State HIV Prevention Funding Trends Against HIV Diagnosis Rates From 2008 to 2023" by Evan Hall Botswana Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana

Science Spotlight: GLP-1 Receptor Agonists

"Real-World Outcomes of Tirzepatide Use in People With HIV With and Without Diabetes" by Daniel Lee UCSD Medical Center Owen Clinic, San Diego, CA, USA

Science Spotlight: Immunity to Mpox After Infection and Vaccination

"Association Between Mpox Vaccination and Disease Severity in Washington State, 2023-2025" by Benjamin Meana Washington State Department of Health, Olympia, WA, USA

Science Spotlight: Mpox: Pathogenesis, Diagnosis, Clinical Predictors, and Resistance

"Tecovirimat Treatment of Mpox Leads to Emergent Resistance in Advanced HIV (ACTG A5418/STOMP)" by Alex Greninger University of Washington, Seattle, WA, USA

Science Spotlight: The Pediatric Reservoir and Immune Response

"Perinatal CMV Coinfection Influences the HIV Reservoir in Individuals With Perinatally Acquired HIV" by Nicole Colantoni Ospedale Pediatrico Bambino Gesu, Rome, Italy

Science Spotlight: Therapeutic Vaccines and bNAbs: Remission in Children and Adolescents

"RV534 Trial: T-Cell Responses and HIV Reservoir Change in HIVIS-DNA/MVA-CMDR+TLR4 Vaccinated Youth" by Arianna Rotili University of Rome Tor Vergata, Rome, Italy

Science Spotlight: TLD and HIV Treatment in LMIC: What Are We Learning?

"Validity of Point-of-Care Urine Tenofovir Testing to Differentiate Viremia Versus Suppression on TLD" by Suzanne McCluskey Massachusetts General Hospital, Boston, MA, USA

Science Spotlight: TLD and HIV Treatment in LMIC: What Are We Learning?

"Short Text Messages Improve Antiretroviral Adherence Among People Living With HIV in Georgia" by Otar Chokoshvili T. Tsertsvadze Infectious Diseases AIDS and Clinical Immunology Research Center, Tbilisi, Georgia

Science Spotlight: Transcription in the HIV Reservoir

"Majority of Infected Cells in Peripheral Blood of PWH on ART Transcribe Cell-Associated HIV gag RNA" by Alexander Pasternak Amsterdam University Medical Centers, Amsterdam, Netherlands

Science Spotlight: Weight Gain and Metabolic Disorders

"Two Years of Dolutegravir (DTG) Use Did Not Affect Body Composition in People Without HIV Infection" by Cleyde S. C. Marconi Federal University of Bahia, Salvador, Brazil

Symposium: In and Out of the Capsid

"5-Minute Moderator Opening: Background and Setting the Stage" by Theodora Hatziioannou Rockefeller University, New York, NY, USA

Symposium: In and Out of the Capsid

"Questions and Answers" by Theodora Hatziioannou Rockefeller University, New York, NY, USA

Symposium: In and Out of the Capsid

"Integrase Anchors Viral RNA to the HIV-1 Capsid Interior" by Peter Cherepanov The Francis Crick Institute, London, UK

Symposium: In and Out of the Capsid

"Capsid-Mediated Protection of HIV-1 Nucleic Acids From Innate Immune Detection" by Sebla Kutluay Washington University in St Louis, St Louis, MO, USA

Symposium: In and Out of the Capsid

"HIV-1 Uncoating Site Dictates Sites of Integration" by Vinay K. Pathak National Cancer Institute at Frederick, Frederick, MD, USA

Symposium: Strategic and Resilient Responses to the Funding Crisis Across Africa

"Sustaining Successful HIV Programs Across Africa: The Impact of Shifts in Funding" by Geoff P. Garnett London School of Hygiene & Tropical Medicine, London, UK

Symposium: Strategic and Resilient Responses to the Funding Crisis Across Africa

"Questions and Answers" by Ruanne V. Barnabas Massachusetts General Hospital, Boston, MA, USA

Symposium: Strategic and Resilient Responses to the Funding Crisis Across Africa

"Global Cuts, Local Consequences: Community Impact and Response to the HIV Funding Crisis" by Solange L. Baptiste ITPC Global, Johannesburg, South Africa

Symposium: Strategic and Resilient Responses to the Funding Crisis Across Africa

"Circumventing the Cascading Crisis: Impacts of US Government Policies on Research and Adaptations in Africa" by Andrew D. Kambugu Infectious Disease Institute, Kampala, Uganda

Symposium: When I'm 64: Neurodegeneration, Epigenetic Aging, and Cognition in Older People With HIV

"Neurodegeneration and Dementia Risk in Older Adults With HIV: Biomarkers and Epidemiology" by Alan Winston Imperial College London, London, UK

Symposium: When I'm 64: Neurodegeneration, Epigenetic Aging, and Cognition in Older People With HIV

"Questions and Answers" by Paola M. P. Cinque IRCCS San Raffaele Scientific Institute, Milan, Italy

Symposium: When I'm 64: Neurodegeneration, Epigenetic Aging, and Cognition in Older People With HIV

"Epigenetic Aging of the Brain in HIV: Methylation Clocks and Antiretroviral-Related Changes" by Michael J. Corley University of California San Diego Medical Center, La Jolla, CA, USA

Symposium: When I'm 64: Neurodegeneration, Epigenetic Aging, and Cognition in Older People With HIV

"Cognitive Aging in HIV: Clinical Assessment and Management" by Shibani S. Mukerji Massachusetts General Hospital, Boston, MA, USA

Tuesday Plenary Session

"CROI Program Committee Chair Welcome to Tuesday" by Nicolas Chomont Université de Montréal, Montreal, Canada

Tuesday Plenary Session

"GLP-1 Receptor Agonists: Are They a Cure for Everything?" by Todd T. Brown The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Tuesday Plenary Session

"Syphilis and Superbugs: Sexually Transmitted Infections in the Era of HIV Control" by Jeanne Marrazzo Infectious Diseases Society of America, Arlington, VA, USA

Oral Abstract: HIV Reservoirs and Cure Strategies

"A Posttranscriptional Block Limits HIV Env Expression in Reactivated Cells From PWH on ART" by Jonathan Richard Centre de Recherche du CHUM, Montreal, Canada

Oral Abstract: HIV Reservoirs and Cure Strategies

"Altered Viral Kinetics at ATI After Dual LS-bNAbs Plus ART: A Preliminary Analysis of RIO Arm B" by Julia Edgar University of Oxford, Oxford, UK

Oral Abstract: HIV Reservoirs and Cure Strategies

"Autologous Neutralising Antibodies and Effective CD8 T Cells Maintain HIV Postintervention Control" by Katie Fisher Aarhus University, Aarhus, Denmark

Oral Abstract: HIV Reservoirs and Cure Strategies

"Bacteria-Specific CD4+ T Cells Contribute to HIV Persistence During ART" by Armando Espinosa Ortiz Université de Montréal, Montreal, Canada

Oral Abstract: HIV Reservoirs and Cure Strategies

"Questions and Answers (Part 1)" by

Oral Abstract: HIV Reservoirs and Cure Strategies

"CD4-Targeted IL-15 Enhanced bNAb Activity and Improved SHIV Control After Treatment Interruption" by Jeffrey Murry Gilead Sciences, Inc, Foster City, CA, USA

Oral Abstract: HIV Reservoirs and Cure Strategies

"Decoding the Somatic Mutation Landscape in Persisting HIV-1-Infected CD4+ T Clones" by Marie Armani-Tourret Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA

Oral Abstract: HIV Reservoirs and Cure Strategies

"Ibalizumab-Targeted Delivery of Tat mRNA Transactivates Provirus Expression In Vivo" by Edward F. Kreider University of Pennsylvania, Philadelphia, PA, USA

Oral Abstract: HIV Reservoirs and Cure Strategies

"Immune-Mediated Viral Control With Budigalimab ± Trosunilimab: First Results of Phase II Global RCT" by Ana Gabriela Pires Dos Santos AbbVie, Inc, North Chicago, IL, USA

Oral Abstract: HIV Reservoirs and Cure Strategies

"Questions and Answers (Part 2)" by

Oral Abstract: Next-Generation HIV Strategies for Children and Adolescents: Breakthroughs in Pediatric HIV Prevention, Treatment, and Care

"DOLPHIN-KIDS: Phase I/II Trial of Dolutegravir With 3HP for TB Prevention in Children With HIV" by Nicole Salazar-Austin The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Oral Abstract: Next-Generation HIV Strategies for Children and Adolescents: Breakthroughs in Pediatric HIV Prevention, Treatment, and Care

"Empiric Valganciclovir Reduces Mortality in Infants Living With HIV and Severe Pneumonia" by Pablo Rojo Fundación para la Investigación Biomédica Hospital 12 de Octubre, Madrid, Spain

Oral Abstract: Next-Generation HIV Strategies for Children and Adolescents: Breakthroughs in Pediatric HIV Prevention, Treatment, and Care

"Viral Control Among Children in Botswana Receiving Combination Broadly Neutralizing Antibodies" by Gbolahan Ajibola Botswana Harvard AIDS Institute Partnership, Gabarone, Botswana

Oral Abstract: Next-Generation HIV Strategies for Children and Adolescents: Breakthroughs in Pediatric HIV Prevention, Treatment, and Care

"Very Early ART Initiation Associated With Sustained Aviremia in Time-to-Rebound Pediatric ATI" by Gabriela Z. L. Cromhout University of KwaZulu-Natal, Durban, South Africa

Oral Abstract: Next-Generation HIV Strategies for Children and Adolescents: Breakthroughs in Pediatric HIV Prevention, Treatment, and Care

"Questions and Answers (Part 1)" by

Oral Abstract: Next-Generation HIV Strategies for Children and Adolescents: Breakthroughs in Pediatric HIV Prevention, Treatment, and Care

"DTG/3TC Is Noninferior to DTG-Based 3-Drug ART in Children With HIV: D3/Penta 21 Week-96 Results" by Anna Turkova MRC Clinical Trials Unit at UCL, London, UK

Oral Abstract: Next-Generation HIV Strategies for Children and Adolescents: Breakthroughs in Pediatric HIV Prevention, Treatment, and Care

"Long-Acting Cabotegravir+Rilpivirine in Adolescents: IMPAACT 2017 Week 96 & End-of-Study Results" by Aditya Gaur St Jude Children's Research Hospital, Memphis, TN, USA

Oral Abstract: Next-Generation HIV Strategies for Children and Adolescents: Breakthroughs in Pediatric HIV Prevention, Treatment, and Care

"Improved Viral Suppression and Retention: Randomized Trial of an Adolescent Transition Intervention" by Brian Zanoni Emory University, Atlanta, GA, USA

Oral Abstract: Next-Generation HIV Strategies for Children and Adolescents: Breakthroughs in Pediatric HIV Prevention, Treatment, and Care

"Immunogenicity of 2- Versus 3-Dose HPV Vaccination by HIV Infection Status in Eswatini" by Harriet Nuwagaba-Biribonwoha ICAP at Columbia University, New York, NY, USA

Oral Abstract: Next-Generation HIV Strategies for Children and Adolescents: Breakthroughs in Pediatric HIV Prevention, Treatment, and Care

"Questions and Answers (Part 2)" by

Oral Abstract: Three Battles - One Stage: TB, Hepatitis, and Hepatocellular Cancer

"Efficacy and Safety of BLV 2 or 10 mg in CHD Including Patients With HIV/HBV: MYR301 Final Results" by David Wyles Denver Health Medical Center, Denver, CO, USA

Oral Abstract: Three Battles - One Stage: TB, Hepatitis, and Hepatocellular Cancer

"Hepatitis B Reactivation/Infection in People With HIV on Tenofovir-Sparing Antiretroviral Therapy" by Grace Haser University of California San Francisco, San Francisco, CA, USA

Oral Abstract: Three Battles - One Stage: TB, Hepatitis, and Hepatocellular Cancer

"Long-Term Outcomes of Liver Transplant Recipients Living With HIV: A Multicenter Case-Control Study" by José M. Miró Hospital Clinic of Barcelona, Barcelona, Spain

Oral Abstract: Three Battles - One Stage: TB, Hepatitis, and Hepatocellular Cancer

"Early Detection of HCC via Active Surveillance in Persons With HIV in Uganda at High Risk" by Katuku Jim Aizire The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

Oral Abstract: Three Battles - One Stage: TB, Hepatitis, and Hepatocellular Cancer

"Questions and Answers (Part 1)" by

Oral Abstract: Three Battles - One Stage: TB, Hepatitis, and Hepatocellular Cancer

"One-Month Versus 3-Month Rifapentine-Based Tuberculosis Preventive Therapy in People With HIV" by Anchalee Avihingsanon Thai Red Cross AIDS Research Centre, Bangkok, Thailand

Oral Abstract: Three Battles - One Stage: TB, Hepatitis, and Hepatocellular Cancer

"Twice-Daily Dolutegravir With a 4-Month Rifapentine-Based Regimen for HIV-Associated Tuberculosis" by Sean Wasserman St George's University of London, London, UK

Oral Abstract: Three Battles - One Stage: TB, Hepatitis, and Hepatocellular Cancer

"DOLPHIN-Moms: Pharmacokinetics and HIV Suppression With Once-Daily Dolutegravir and 3HP in Pregnancy" by Jyoti S. Mathad Weill Cornell Medicine, New York, NY, USA

Oral Abstract: Three Battles - One Stage: TB, Hepatitis, and Hepatocellular Cancer

"Safety and Treatment Completion of 1HP Versus 3HP in People With HIV: The One-to-Three Trial" by Jayajothi Moodley The Aurum Institute, Johannesburg, South Africa

Oral Abstract: Three Battles - One Stage: TB, Hepatitis, and Hepatocellular Cancer

"Novel Linezolid Dosing With Bedaquiline, Delamanid, and Clofazimine for Drug-Resistant TB Treatment" by Constance A. Benson University of California San Diego, La Jolla, CA, USA

Oral Abstract: Three Battles - One Stage: TB, Hepatitis, and Hepatocellular Cancer

"Questions and Answers (Part 2)" by

Oral Abstract: We Thought You'd Never Ask: Improving HIV Screening and Testing

"Cluster-Randomized Stepped-Wedge Trial of HIV Rapid Testing and Risk Assessment in Primary Care" by Maria Jesus Perez Elias Ramon y Cajal Hospital, Madrid, Spain

Oral Abstract: We Thought You'd Never Ask: Improving HIV Screening and Testing

"Enhanced Opt-Out HIV Screening & Linkage to Care for 216K Patients at 13 Community Health Centers" by Timothy Long MD Health Choice Network, Miami, FL, USA

Oral Abstract: We Thought You'd Never Ask: Improving HIV Screening and Testing

"Electronic Health Record-Driven Universal HIV Screening and Missed Opportunities in Southeastern US" by David E. Hudon Prisma Health, Greenville, SC, USA

Oral Abstract: We Thought You'd Never Ask: Improving HIV Screening and Testing

"Using Machine Learning to Optimize HIV Risk Prediction and Case Identification in Eastern Kenya" by Peter Kyalo Center for International Health, Education and Biosecurity (CIHEB) Kenya, Nairobi, Kenya

Oral Abstract: We Thought You'd Never Ask: Improving HIV Screening and Testing

"Questions and Answers (Part 1)" by

Oral Abstract: We Thought You'd Never Ask: Improving HIV Screening and Testing

"Global Analysis of HIV Oral PrEP-to-Need Ratios (PnR) in 2025" by Andrew Hill University of Liverpool, Liverpool, UK

Oral Abstract: We Thought You'd Never Ask: Improving HIV Screening and Testing

"The Impact of SEARCH Community Precision Health on HIV Incidence in Rural Kenya and Uganda" by Gabriel Chamie University of California San Francisco, San Francisco, CA, USA

Oral Abstract: We Thought You'd Never Ask: Improving HIV Screening and Testing

"Urine Tenofovir and POC Viral Load Testing After ART Start: Week 72 Outcomes of STREAM-HIV Trial" by Paul K. Drain University of Washington, Seattle, WA, USA

Oral Abstract: We Thought You'd Never Ask: Improving HIV Screening and Testing

"Evaluating the Viability of Self-Collected Blood for Remotely Testing HIV Suppression Among MSM" by Jeffrey Johnson Centers for Disease Control and Prevention, Atlanta, GA, USA

Oral Abstract: We Thought You'd Never Ask: Improving HIV Screening and Testing

"Questions and Answers (Part 2)" by

Themed Discussion: Extra Large Challenges in Steatotic Liver Disease

"Session Overview" by Mark Sulkowski The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Themed Discussion: Extra Large Challenges in Steatotic Liver Disease

"Simple Adiposity Measures Identify MASLD in People With HIV: Results From a US Multicenter Cohort" by Kara Wegermann Duke University School of Medicine, Durham, NC, USA

Themed Discussion: Extra Large Challenges in Steatotic Liver Disease

"Performance of Prediction Scores for Steatotic Liver Disease in Thai PWH on InSTI-Based ART" by Napon Hiranburana HIV Netherlands Australia Thailand Research Collaboration, Bangkok, Thailand

Themed Discussion: Extra Large Challenges in Steatotic Liver Disease

"Effect of DTG/3TC vs BIC/FTC/TAF on Steatotic Liver Disease: 96-Week Analysis of PASO-DOBLE Trial" by Juan Macias University of Sevilla, Sevilla, Spain

Themed Discussion: Extra Large Challenges in Steatotic Liver Disease

"Longitudinal Associations of Semaglutide With Liver Fibrosis Score in People With HIV" by Jimmy Ma University of Washington, Seattle, WA, USA

Themed Discussion: Extra Large Challenges in Steatotic Liver Disease

"Discussion With Audience Questions and Answers" by

Themed Discussion: Machines, Models, and Messages

"Session Overview" by Ravi Goyal University of California San Diego, La Jolla, CA, USA

Themed Discussion: Machines, Models, and Messages

"Machine Learning and Longitudinal Data to Predict Unsuppressed HIV Viral Load in Rwanda, 2020-2025" by Ndinda Christian Rwanda Biomedical Centre, Kigali, Rwanda

Themed Discussion: Machines, Models, and Messages

"Effect of Machine-Learning-Guided Previsit Outreach to Patients at High Risk to Miss HIV Visits" by Joseph W. Hogan Brown University, Providence, RI, USA

Themed Discussion: Machines, Models, and Messages

"Sentiment Analysis of WhatsApp Messages to Identify Unrecognized HIV Prevention Needs in Kenya" by Jessica Haberer Massachusetts General Hospital, Boston, MA, USA

Themed Discussion: Machines, Models, and Messages

"Measuring Provider Quality of Care in Tanzania Using Large Language Models" by Alaa Abdellatif University of California San Francisco, San Francisco, CA, USA

Themed Discussion: Machines, Models, and Messages

"Discussion With Audience Questions and Answers" by

Themed Discussion: Precision Comes to Public Health

"Session Overview" by Suzue Saito ICAP at Columbia University, New York, NY, USA

Themed Discussion: Precision Comes to Public Health

"Quantifying Uncertainty in HIV Transmission Risk From Persons With Low-Level Viremia" by Michael Martin The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

Themed Discussion: Precision Comes to Public Health

"Network Bridges to Predict Emerging HIV Transmission Hotspots in North Carolina" by Ann Dennis University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Themed Discussion: Precision Comes to Public Health

"Mapping Recent HIV Infections Among MSM in Thailand: Data-Driven Insights for Targeted Prevention" by Michael Reid

Themed Discussion: Precision Comes to Public Health

"Progress Towards HIV Epidemic Control Among Young Key Populations in India" by Eshan U. Patel The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

Themed Discussion: Precision Comes to Public Health

"Discussion With Audience Questions and Answers" by

Themed Discussion: Targeting the HIV Reservoir: Novel Cure Strategies

"Session Overview" by Marina Caskey The Rockefeller University, New York, NY, USA

Themed Discussion: Targeting the HIV Reservoir: Novel Cure Strategies

"Targeting the HIV-1 Latent Reservoir With Tat-CRISPR Lipid Nanoparticles" by Keely Gliwa University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Themed Discussion: Targeting the HIV Reservoir: Novel Cure Strategies

"Bispecific Biologics That Activate Latent HIV-1 Ex Vivo and In Vivo" by David D. Ho Aaron Diamond AIDS Research Center, New York, NY, USA

Themed Discussion: Targeting the HIV Reservoir: Novel Cure Strategies

"Combination Therapy With Tat mRNA and a TLR9 Agonist Delays Post-ATI Rebound in the NHP Model" by Takuto Nogimori National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan

Themed Discussion: Targeting the HIV Reservoir: Novel Cure Strategies

"Markedly Reduced Mutability of Networked Epitopes Promotes CTL Clearance of the Latent HIV Reservoir" by Fernando B. Senjobe Harvard Medical School, Boston, MA, USA

Themed Discussion: Targeting the HIV Reservoir: Novel Cure Strategies

"Discussion With Audience Questions and Answers" by

Science Spotlight: Biomarkers of Aging

"Mitochondrial Function and Cardiometabolic Health in People With HIV in South Africa and Kenya" by Hans Strijdom Stellenbosch University, Cape Town, South Africa

Science Spotlight: Evolving Insights Into the Health of Pregnant Women With HIV

"Effect of Initiating Dolutegravir and Efavirenz-Based ART on the Vaginal Microbiota in Pregnancy" by Charlotte-Eve Short Imperial College London, London, UK

Science Spotlight: Extra Large Challenges in Steatotic Liver Disease

"Simple Adiposity Measures Identify MASLD in People With HIV: Results From a US Multicenter Cohort" by Kara Wegermann Duke University School of Medicine, Durham, NC, USA

Science Spotlight: Extra Large Challenges in Steatotic Liver Disease

"Prevalence of Steatotic Liver Disease in Pregnant South African Women Living With and Without HIV" by Mustafa Shuaib University of Cape Town, Cape Town, South Africa

Science Spotlight: Extra Large Challenges in Steatotic Liver Disease

"Prevalence and Risk Factors for Steatotic Liver Disease in PWH With Resolved HCV" by Kara Wegermann Duke University School of Medicine, Durham, NC, USA

Science Spotlight: Extra Large Challenges in Steatotic Liver Disease

"Elevated Triglyceride and Ceramide Metabolites in MASLD Among PWH" by Kara Wegermann Duke University School of Medicine, Durham, NC, USA

Science Spotlight: Global STI Epidemiology

"Sexually Transmitted Enteric Infections in Southern Taiwan, 2019-2024" by Chin-Shiang Tsai National Cheng Kung University Hospital, Tainan, Taiwan

Science Spotlight: HIV Host Interaction

"Development of a Fluorescence Immunoassay for Measuring HIV Antibodies and Soluble gp120 in PLWH" by Alan F. Garcia University of Hawaii at Manoa, Honolulu, HI, USA

Science Spotlight: Molecular Epidemiology, Phylogenetics, and HIV Diversity

"Comparing Molecular and Time-Space HIV Cluster Detection Methods in Rural Washington, 2020-2024" by Nicole Adams Washington State Department of Health, Olympia, WA, USA

Science Spotlight: Mortality, Advanced HIV, and Clinical Outcomes

"Risk Factors of HIV/AIDS Mortality Among HIV Recipients of Care in Southern Nigeria" by Afeez Oyetola Howard University Global Initiative Nigeria

Science Spotlight: Novel Antiretroviral Agents and Combinations: The Long Game

"Phase III Efficacy and Safety of Switch From B/F/TAF to Single-Tablet BIC/LEN in ARTISTRY-2" by Eric Meissner Medical University of South Carolina, Charleston, SC, USA

Science Spotlight: Novel Antiretroviral Agents and Combinations: The Long Game

"Once-Weekly Islatravir Plus Lenacapavir Maintains HIV-1 Suppression Through 96 Weeks: Phase II Study" by Amy Colson Community Resource Initiative, Boston, MA, USA

Science Spotlight: Novel Interventions

"RCT of Mobile Health Unit Versus Patient Navigation to Increase PrEP in Criminal Legal-Involved PWUD" by Sandra A. Springer Yale University, New Haven, CT, USA

Science Spotlight: Novel Interventions

"Closing PrEP Access Gaps: Results From the First Legalized Mobile Retail Pharmacy Clinic" by Sandra A. Springer Yale University, New Haven, CT, USA

Science Spotlight: Programmatic Advances in Maternal Health

"Gaps in Care Transitions Between Perinatal and Postpartum Care for Chronic Hepatitis B Infection" by M. Elle Saine Hospital of the University of Pennsylvania, Philadelphia, PA, USA

Science Spotlight: Recent Progress in HIV Vaccine Development

"Rectal Microbiome Associations With HIV Vaccine-Induced Binding Antibody Responses in RV306" by Nel Marín-Sánchez IrsiCaixa, Badalona, Spain

Science Spotlight: The Realities of Doxy-PEP

"Impact of Doxycycline Postexposure Prophylaxis on Antibiotic Use at a Boston Sexual Health Clinic" by Rachel Mittelstaedt Massachusetts General Hospital, Boston, MA, USA

Symposium: 30 Years of Viral Suppression: A Biologic Reset?

"HIV Reservoir: Persistence and Expansion Under Long-Term ART" by John W. Mellors University of Pittsburgh, Pittsburgh, PA, USA

Symposium: 30 Years of Viral Suppression: A Biologic Reset?

"Questions and Answers" by Michael M. Lederman Case Western Reserve University, Cleveland, OH, USA

Symposium: 30 Years of Viral Suppression: A Biologic Reset?

"HIV-Specific T-Cell Responses in People With HIV on Long-Term ART" by Victor Appay University of Bordeaux, Bordeaux, France

Symposium: 30 Years of Viral Suppression: A Biologic Reset?

"Beyond Undetectable: Chronic Inflammation and Multimorbidity in People With HIV on ART" by Irini Sereti National Institute of Allergy and Infectious Diseases, Baltimore, MD, USA

Symposium: Counting and Caring for Transgender and Gender-Diverse Individuals

"Epidemiology" by Stefan Baral The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

Symposium: Counting and Caring for Transgender and Gender-Diverse Individuals

"Questions and Answers" by Jade Ghosn Assistance Publique – Hôpitaux de Paris, Paris, France

Symposium: Counting and Caring for Transgender and Gender-Diverse Individuals

"Clinical Management" by Asa E. Radix Callen-Lorde Community Health Center, New York, NY, USA

Symposium: Counting and Caring for Transgender and Gender-Diverse Individuals

"Community Evidence, System Change: Transgender Leadership in Sustaining HIV Care" by Rena Janamnuaysook Institute of HIV Research and Innovation, Bangkok, Thailand

Symposium: The Long Game: Progress and the Promise of Long-Acting ART for Treatment

"Clinical Trials and New Drugs in the Pipeline" by Onyema Ogbuagu Yale University, New Haven, CT, USA

Symposium: The Long Game: Progress and the Promise of Long-Acting ART for Treatment

"Panel Discussion" by Eric S. Daar University of California Los Angeles, Los Angeles, CA, USA

Symposium: The Long Game: Progress and the Promise of Long-Acting ART for Treatment

"Panel Discussion" by Gastón Devisich Fundación Huésped, Buenos Aires, Argentina

Symposium: The Long Game: Progress and the Promise of Long-Acting ART for Treatment

"Panel Discussion" by Rosie Mngqibisa Enhancing Care Foundation, Durban, South Africa

Symposium: The Long Game: Progress and the Promise of Long-Acting ART for Treatment

"Challenges and Solutions to Implementation" by Aadia Rana University of Alabama at Birmingham, Birmingham, AL, USA

Wednesday Plenary Session

"CROI Program Committee Chair Welcome to Wednesday" by Wafaa M. El-Sadr Columbia University, New York, NY, USA

Wednesday Plenary Session

"Successes in HIV-1 Vaccine Design: Accelerating Completion of One of Science's Most Difficult Vaccines" by Kevin O. Saunders Duke Human Vaccine Institute, Durham, NC, USA

Wednesday Plenary Session

"Tuberculosis in Children and Adolescents: From Neglect to Action" by Anneke C. Hesseling Stellenbosch University, Cape Town, South Africa

Oral Abstract: Extending the Reach: Long-Acting Antiviral and Novel Delivery

"Safety, Pharmacokinetics, and Antiviral Activity of GS-3242, a Novel Long-Acting Injectable InSTI" by Samir Gupta Indiana University Health, Indianapolis, IN, USA

Oral Abstract: Extending the Reach: Long-Acting Antiviral and Novel Delivery

"Injectable HIV-1 Capsid Inhibitor VH4011499 (VH-499) Formulation Supports Ultra-Long-Acting Dosing" by Nilay Thakkar GSK plc, Collegeville, PA, USA

Oral Abstract: Extending the Reach: Long-Acting Antiviral and Novel Delivery

"Pharmacokinetics and Evaluation of Potential Dosing Regimens for Long-Acting VH4524184" by Hyunmoon Back GSK plc, Collegeville, PA, USA

Oral Abstract: Extending the Reach: Long-Acting Antiviral and Novel Delivery

"DOR/ISL (100/0.25 mg) vs BIC/FTC/TAF for Initial HIV-1 Therapy: Week 48 Results of a Phase III Study" by Juergen K. Rockstroh Bonn University Hospital, Bonn, Germany

Oral Abstract: Extending the Reach: Long-Acting Antiviral and Novel Delivery

"Questions and Answers (Part 1)" by

Oral Abstract: Extending the Reach: Long-Acting Antiviral and Novel Delivery

"Maintenance of HIV Suppression at 12 Months With VH3810109 (N6LS) Q4M + CAB LA QM: The EMBRACE Study" by Charlotte-Paige Rolle Orlando Immunology Center, Orlando, FL, USA

Oral Abstract: Extending the Reach: Long-Acting Antiviral and Novel Delivery

"Safety and Antiviral Effect of 10E8.4/Ibalizumab in People With HIV: A Phase Ib Trial" by Trevor A. Crowell Henry M Jackson Foundation, Bethesda, MD, USA

Oral Abstract: Extending the Reach: Long-Acting Antiviral and Novel Delivery

"Sustained DNA-Encoded SARS-CoV-2 Antibody Expression and Safety Through 96 Weeks" by Pablo Tebas University of Pennsylvania, Philadelphia, PA, USA

Oral Abstract: Extending the Reach: Long-Acting Antiviral and Novel Delivery

"Phase III Efficacy and Safety of Switch From Complex Regimen to Single-Tablet BIC/LEN in ARTISTRY-1" by Chloe M. Orkin Queen Mary University of London, London, UK

Oral Abstract: Extending the Reach: Long-Acting Antiviral and Novel Delivery

"Questions and Answers (Part 2)" by

Oral Abstract: From Good to Great: Advancing Treatment and Prevention

"HIV Testing and Treatment Gaps in Subgroups of Men With HIV: Insights From 7 African countries" by Craig J. Heck Columbia University Irving Medical Center, New York, NY, USA

Oral Abstract: From Good to Great: Advancing Treatment and Prevention

"Impact of Person-Centered Care Intervention on HIV Treatment Failure Response in Zambia" by Kombatende Sikombe Centre for Infectious Disease Research in Zambia, Lusaka, Zambia

Oral Abstract: From Good to Great: Advancing Treatment and Prevention

"The START mHealth Application Reduces Risk of Virologic Rebound in Men With HIV Who Use Stimulants" by Adam W. Carrico Florida International University, Miami, FL, USA

Oral Abstract: From Good to Great: Advancing Treatment and Prevention

"Effects of a Coping Intervention on Viral Load Among South African Women With HIV and Sexual Trauma" by Kathleen J. Sikkema Columbia University, New York, NY, USA

Oral Abstract: From Good to Great: Advancing Treatment and Prevention

"Questions and Answers (Part 1)" by

Oral Abstract: From Good to Great: Advancing Treatment and Prevention

"SMART ART: A Randomized Clinical Trial of Adaptive Strategies for HIV Viral Suppression in S Africa" by Ruanne V. Barnabas Massachusetts General Hospital, Boston, MA, USA

Oral Abstract: From Good to Great: Advancing Treatment and Prevention

"Early Findings From Cabotegravir Injectable HIV PrEP Rollout in Malawi: Uptake and Continuation" by Deborah Hoege Georgetown University, Washington, DC, USA

Oral Abstract: From Good to Great: Advancing Treatment and Prevention

"Randomised Pilot of Pharmacy-Based Collection of PrEP Refills Among Female Sex Workers in Zimbabwe" by Constancia C. Watadzaushe Centre for Sexual Health and HIV/AIDS Research Zimbabwe, Harare, Zimbabwe

Oral Abstract: From Good to Great: Advancing Treatment and Prevention

"Integrating HIV and Hypertension Care Improves Blood Pressure in Uganda: A Cluster Randomized Trial" by Chris T. Longenecker University of Washington, Seattle, WA, USA

Oral Abstract: From Good to Great: Advancing Treatment and Prevention

"Questions and Answers (Part 2)" by

Oral Abstract: Manipulating the HIV Immune Response for Prevention and Treatment

"Autologous Functional Antibody Dynamics in the Context of bNAb Therapy for HIV" by Boris Juelg Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA

Oral Abstract: Manipulating the HIV Immune Response for Prevention and Treatment

"Autologous Monoclonal Neutralizing Antibodies as a Promising Path to a Functional HIV-1 Cure" by Junlin Zhuo The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Oral Abstract: Manipulating the HIV Immune Response for Prevention and Treatment

"In Vivo HSC Gene Therapy Drives Sustained eCD4-Ig Expression Primarily by B-Cells for SIV Prevention" by John K. Bui Fred Hutchinson Cancer Center, Seattle, WA, USA

Oral Abstract: Manipulating the HIV Immune Response for Prevention and Treatment

"Shared Resistance Pathways to CD4bs bNAbs Between Viremic SHIV NHP Model and Human Clinical Trials" by Jiajie Li University of Pennsylvania, Philadelphia, PA, USA

Oral Abstract: Manipulating the HIV Immune Response for Prevention and Treatment

"Questions and Answers (Part 1)" by

Oral Abstract: Manipulating the HIV Immune Response for Prevention and Treatment

"Assessing Early Immune Response to HIV Rebound in Viremic Controllers and Noncontrollers" by Anna Farrell-Sherman Fred Hutchinson Cancer Center, Seattle, WA, USA

Oral Abstract: Manipulating the HIV Immune Response for Prevention and Treatment

"A Conserved NK-Like KIR+ CD8+ T-Cell Subset Mediates Exceptional HIV Control and Functional HBV Cure" by Gaurav Gaiha Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA

Oral Abstract: Manipulating the HIV Immune Response for Prevention and Treatment

"Innate Immune Imprints Shape HIV-1 Reservoir Cell Persistence During Long-Term ART" by Toong Seng Tan Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA

Oral Abstract: Manipulating the HIV Immune Response for Prevention and Treatment

"Repeated IL-10/PD-1 Blockades Potently Control SIV Rebound and Limit Reservoir in the Absence of ART" by Mirko Paiardini Emory University, Atlanta, GA, USA

Oral Abstract: Manipulating the HIV Immune Response for Prevention and Treatment

"Questions and Answers (Part 2)" by

Oral Abstract: Partners, Pills, and Penicillin: Progress in Prevention

"Declining HIV Incidence and Differential PrEP Effectiveness Among Key Populations With STIs, 2014-25" by Chase A. Cannon University of Washington, Seattle, WA, USA

Oral Abstract: Partners, Pills, and Penicillin: Progress in Prevention

"HIV Incidence Could Rise by 73% in 30 States if Ryan White Ends: A Simulation Study" by Melissa Schnure The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Oral Abstract: Partners, Pills, and Penicillin: Progress in Prevention

"HIV Incidence in a Nationwide Cohort of Transgender Women in the United States and Puerto Rico" by Sari L. Reisner University of Michigan, Ann Arbor, MI, USA

Oral Abstract: Partners, Pills, and Penicillin: Progress in Prevention

"Awareness of Sex Partners’ HIV Status and Risk of HIV Acquisition: Rakai, Uganda" by Victor Ssempijja Leidos Biomedical Research, Inc, Frederick, MD, USA

Oral Abstract: Partners, Pills, and Penicillin: Progress in Prevention

"Questions and Answers (Part 1)" by

Oral Abstract: Partners, Pills, and Penicillin: Progress in Prevention

"Comparative Effectiveness of 3 Benzathine Penicillin G-Based Regimens in PWH With Early Syphilis" by Kai Hsiang Chen National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan

Oral Abstract: Partners, Pills, and Penicillin: Progress in Prevention

"Early Syphilis and HIV Among Adolescents: United States, 20142-023" by Daniel Gore Centers for Disease Control and Prevention, Atlanta, GA, USA

Oral Abstract: Partners, Pills, and Penicillin: Progress in Prevention

"Pritelivir for Refractory HSV Infections in Immunocompromised Patients: Results of a Phase III Trial" by Jean-Michel Molina Assistance Publique – Hôpitaux de Paris, Paris, France

Oral Abstract: Partners, Pills, and Penicillin: Progress in Prevention

"Meningococcal B (4CMenB) Vaccination for the Prevention of Gonorrhea in Men Who Have Sex With Men" by Kate L. Seib Griffith University, Southport, Australia

Oral Abstract: Partners, Pills, and Penicillin: Progress in Prevention

"Questions and Answers (Part 2)" by

Themed Discussion: Advancing Mental Health for Youth With HIV

"Session Overview" by Claude A. Mellins Columbia University Irving Medical Center, New York, NY, USA

Themed Discussion: Advancing Mental Health for Youth With HIV

"Depression, Anxiety, and Viral Suppression Among Adolescents and Young Adults in 9 African Countries" by Jiayu Wang University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Themed Discussion: Advancing Mental Health for Youth With HIV

"Implementation of a Mental Health Intervention for Youth With HIV in Kenya" by Pamela Kohler University of Washington, Seattle, WA, USA

Themed Discussion: Advancing Mental Health for Youth With HIV

"Primary Outcomes of SYV (Voice of Youth) Mental Health Intervention: A Randomized Trial in Tanzania" by Dorothy Dow Duke University Medical Center, Durham, NC, USA

Themed Discussion: Advancing Mental Health for Youth With HIV

"Primary Findings of IMPAACT 2016: A RCT of a Youth-Led Mental Health Intervention for Youth With HIV" by Geri Donenberg University of Illinois at Chicago Center for Dissemination and Implementation Science, Chicago, IL, USA

Themed Discussion: Advancing Mental Health for Youth With HIV

"Discussion With Audience Questions and Answers" by

Themed Discussion: Harnessing B-Cells and Antibodies for HIV Control

"Session Overview" by Nicole A. Doria-Rose Vaccine Research Center, Bethesda, MD, USA

Themed Discussion: Harnessing B-Cells and Antibodies for HIV Control

"AAV-Delivered Antibody Reaches Mucosal Sites and Protects Against SHIV Infection in Rhesus Macaques" by Luanna E. L. Vidal University of Miami, Miami, FL, USA

Themed Discussion: Harnessing B-Cells and Antibodies for HIV Control

"Beating the Clock: Timing 10E8.4/iMab Administration to Block SHIV Infection" by Matthew S. Parsons Armed Forces Research Institute of Medical Sciences in Bangkok, Bangkok, Thailand

Themed Discussion: Harnessing B-Cells and Antibodies for HIV Control

"Antigen-Specific Memory B Cells of Extrafollicular Origin May Contribute to ART-Free HIV Control" by Elif Cakan Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA

Themed Discussion: Harnessing B-Cells and Antibodies for HIV Control

"Evidence of Immune Activation During bNAb-Mediated HIV Suppression Following ATI" by Julia A. Wagner University of California San Francisco, San Francisco, CA, USA

Themed Discussion: Harnessing B-Cells and Antibodies for HIV Control

"Discussion With Audience Questions and Answers" by

Themed Discussion: Some Assembly Required: Self-Blood Collection and Testing

"Session Overview" by Michelle Rodolph World Health Organization, Geneva, Switzerland

Themed Discussion: Some Assembly Required: Self-Blood Collection and Testing

"Identifying Where HIV Self-Screening Has Greatest Impact: Analysis of Routine Data in South Africa" by Alexandra de Nooy Amsterdam Institute for Global Health and Development, Amsterdam, Netherlands

Themed Discussion: Some Assembly Required: Self-Blood Collection and Testing

"HIV Self-Testing by Motorcycle-Taxi Drivers: A Novel Approach for Case Detection in Kampala, Uganda" by Edith Namulema Mengo Hospital, Kampala, Uganda

Themed Discussion: Some Assembly Required: Self-Blood Collection and Testing

"Virtual Submission of HIV Viral Load in EPI-LoVE, a Digital Cohort of People Living With HIV in US" by Pamina M. Gorbach University of California Los Angeles, Los Angeles, CA, USA

Themed Discussion: Some Assembly Required: Self-Blood Collection and Testing

"Vending Machines as Stigma-Free Access Points for HIV/Syphilis Testing and Condoms" by David Closs Friends for All, Memphis, TN, USA

Themed Discussion: Some Assembly Required: Self-Blood Collection and Testing

"Discussion With Audience Questions and Answers" by

Themed Discussion: Tuberculosis: Innovative Screening and Diagnostic Approaches

"Session Overview" by Yukari C. Manabe The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Themed Discussion: Tuberculosis: Innovative Screening and Diagnostic Approaches

"Efficiency of Portable Chest X-Ray Compared to Symptom-Based TB Screening in Southwest Nigeria" by Aderonke V. Agbaje Institute of Human Virology Nigeria, Abuja, Nigeria

Themed Discussion: Tuberculosis: Innovative Screening and Diagnostic Approaches

"High Prevalence of Asymptomatic Tuberculosis in an African Cohort of People With HIV (CoVPN 3008-TB)" by Asa Tapley University of Washington, Seattle, WA, USA

Themed Discussion: Tuberculosis: Innovative Screening and Diagnostic Approaches

"The Case for Routine Testing and Empiric Treatment of TB Meningitis in High HIV-Prevalence Settings" by James Milburn Botswana Harvard AIDS Institute Partnership, Gabarone, Botswana

Themed Discussion: Tuberculosis: Innovative Screening and Diagnostic Approaches

"Very Promising New Urinary LAM Assay for Tuberculosis Diagnosis in Children" by Adeline Riondel French National Institute of Health and Medical Research (Inserm), Paris, France

Themed Discussion: Tuberculosis: Innovative Screening and Diagnostic Approaches

"Discussion With Audience Questions and Answers" by

Science Spotlight: Anal Cancer Biomarkers, Screening, and Prevention

"Clinician vs Self-Collected Anal Pap Tests in a Large Ryan White Clinic in the US South" by Hayden Andrews University of Texas Southwestern Medical Center, Dallas, TX, USA

Science Spotlight: HIV-Specific B Cells and Antibodies

"AAV-Delivered Antibody Reaches Mucosal Sites and Protects Against SHIV Infection in Rhesus Macaques" by Luanna E. L. Vidal University of Miami, Miami, FL, USA

Science Spotlight: Neuropathogenesis and Neuroimmunologic Insights

"Depression and Inflammation in Acute HIV: An RDoC-Based PHQ-9 Factor Analysis" by Veronica Wright Kimbrough Ambulatory Care Center, Fort Meade, MD, USA

Science Spotlight: Neuropathogenesis and Neuroimmunologic Insights

"IRE1α–XBP1 Pathway Mediates gp120-Induced Microglial Inflammation and Is Inhibited by TREM1 Blockade" by Ayisha Mahama University of South Dakota, Vermillion, SD, USA

Science Spotlight: Neuropathogenesis and Neuroimmunologic Insights

"Altered Choline and Sphingolipid Metabolism in HTLV-1-Associated Myelopathy" by Jorge Casseb Universidade de São Paulo, São Paulo, Brazil

Science Spotlight: New Tests and Innovative Use of Old Ones

"Pilot Validation of an Enzymatic Assay With Lateral Flow Readout for Long-Term PrEP Adherence" by Carrie H. Lin University of Washington, Seattle, WA, USA

Science Spotlight: Nonhuman Models of HIV Infection

"IL-6 Inhibits T-Cell Lineage Commitment of HSPCs During Pathogenic Retroviral Infection" by Sheikh A. Rahman Emory University, Atlanta, GA, USA

Science Spotlight: Nonhuman Models of HIV Infection

"Characterizing SIV-Infected Plasmacytoid Dendritic Cell Aggregates in Rhesus Macaque Lymph Nodes" by Elizabeth A. Urban Frederick National Laboratory for Cancer Research, Frederick, MD, USA

Science Spotlight: Pharmacokinetics for Vertical Transmission Prevention: bNAbs, Long-Acting Antivirals, and Beyond

"Changes in Doravirine Pharmacokinetics During Pregnancy: A Longitudinal Single-Dose Study" by Angela D. M. Kashuba University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Science Spotlight: Resistance to Other Antiviral Drugs

"CA T107 Polymorphisms in HIV-1 From Lenacapavir-Naive PLWH Do Not Confer or Enhance Resistance" by Ella Begovic University of Pittsburgh, Pittsburgh, PA, USA

Science Spotlight: Retention and Viral Load Suppression

"PositiveLinks for Youth (PL4Y): Promising Results of a Pilot mHealth Intervention for Youth With HIV" by Barbara S. Taylor University of Texas Health Science Center at San Antonio, San Antonio, TX, USA

Science Spotlight: Retention and Viral Load Suppression

"A Roadmap to New Models for Long-Acting Injectable Antiretroviral Administration" by Corrilynn O. Hileman MetroHealth Medical Center, Cleveland, OH, USA

Science Spotlight: Testing and Linkage

"Implementing Self-Screening for Extragenital Chlamydia and Gonorrhea in Low-Resource US Settings" by Loren M. Dobkin University of Michigan, Ann Arbor, MI, USA

Science Spotlight: Viral Suppression and Drug Resistance in Children and Adolescents With HIV

"Global Cohort Analysis of Dolutegravir Viral Response in Children and Adolescents Living With HIV" by Joycelyn A. Dame University of Ghana Medical School, Accra, Ghana

Symposium: Hot Takes on the Clinical Highlights From CROI 2026

"Panel Discussion Plus Questions and Answers from the Audience" by Joseph J. Eron, Jr University of North Carolina Chapel Hill, Chapel Hill, NC, USA

Fatima Kakkar Centre Hospitalier Universitaire Sainte-Justine, Montreal, Canada

Anne F. Luetkemeyer University of California San Francisco, San Francisco, CA, USA

Chloe M. Orkin Queen Mary University of London, London, UK

Deborah Persaud The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Paul E. Sax Brigham and Women's Hospital, Boston, MA, USA

Symposium: Masters of Immunity: The Many Faces of T Cells

"Nonconventional T Cells: Functional Shape Shifters and Conductors of Cytokine Orchestras That Dance With Herpesviruses in People With HIV" by Jennifer Snyder-Cappione Boston University, Boston, MA, USA

Symposium: Masters of Immunity: The Many Faces of T Cells

"Questions and Answers" by Pamela J. Skinner University of Minnesota, Minneapolis, MN, USA

Symposium: Masters of Immunity: The Many Faces of T Cells

"The T-Cell Identity: Conventional T Cells in Action" by R. Brad Jones Weill Cornell Medicine, New York, NY, USA

Symposium: Masters of Immunity: The Many Faces of T Cells

"Engineering T Cells: Improving on Nature" by Anjie Zhen University of California Los Angeles, Los Angeles, CA, USA

Symposium: Time for a Paradigm Shift for Young Pregnant and Breastfeeding Cisgender Women

"HIV Prevention and Treatment Among Young Mothers: Dynamics of Biologic, Psychosocial, and Structural Determinants Across the Life Course" by Elona Toska University of Cape Town, Cape Town, South Africa

Symposium: Time for a Paradigm Shift for Young Pregnant and Breastfeeding Cisgender Women

"Questions and Answers" by Lynn T. Matthews Yale University, New Haven, CT, USA

Symposium: Time for a Paradigm Shift for Young Pregnant and Breastfeeding Cisgender Women

"Continuity of Care During Pregnancy and Postpartum" by Aleny Couto Ministry of Health of Mozambique, Maputo, Mozambique

Symposium: Time for a Paradigm Shift for Young Pregnant and Breastfeeding Cisgender Women

"Ethical and Regulatory System Changes for the Inclusion of Pregnant Women in HIV Research and Development" by Cordelia Katureebe Ministry of Health Uganda, Kampala, Uganda