CROI 2025 - CROI 2025

Themed Discussion: Down But Not Out: Elite Control of HIV

"Session Overview" by Javier Martinez-Pìcado IrsiCaixa, Badalona, Spain

Themed Discussion: Down But Not Out: Elite Control of HIV

"Effect of ART Start Time, ART Duration, and Elite Control on HIV Transcription" by Adam Wedrychowski San Francisco VA Medical Center, San Francisco, CA, USA

Themed Discussion: Down But Not Out: Elite Control of HIV

"Viral Reservoir Characteristics in Lymphoid Tissues of HIV-1 Elite Controllers" by Samantha K. Marzi Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA

Themed Discussion: Down But Not Out: Elite Control of HIV

"CD8+ T Cells Shape the HIV Integration Site Landscape According to the Degree of T-Cell Pressure" by R. Bradley Jones Weill Cornell Medicine, New York, NY, USA

Themed Discussion: Down But Not Out: Elite Control of HIV

"Anti-IL-10/Anti-PD-1 Dual Blockade Leads to IFN-Related HIV Elite Control Signatures" by Susan P. Ribeiro Emory University, Atlanta, GA, USA

Themed Discussion: Down But Not Out: Elite Control of HIV

"Loss of Virological Control 32 Years After HIV-1 Diagnosis in an Exceptional Elite Controller" by Anna Pons-Grífols IrsiCaixa, Badalona, Spain

Themed Discussion: Down But Not Out: Elite Control of HIV

"Discussion with Audience Q&A" by

Themed Discussion: Heart Failure: Hiding in Plain Sight

"Session Overview" by Anoop Shah London School of Hygiene & Tropical Medicine, London, UK

Themed Discussion: Heart Failure: Hiding in Plain Sight

"Mitochondrial Haplogroups and Left Ventricular Dysfunction in People Living With and Without HIV" by Craig Cronin The Johns Hopkins Hospital, Baltimore, MD, USA

Themed Discussion: Heart Failure: Hiding in Plain Sight

"Sex Differences in Myocardial Steatosis in South African Youth With Perinatally-Acquired HIV" by Morne Kahts University of Cape Town, Cape Town, South Africa

Themed Discussion: Heart Failure: Hiding in Plain Sight

"Physician-Confirmed Incident Heart Failure Phenotypes and Etiologies Within CNICS" by Matthew J. Feinstein Northwestern University, Chicago, IL, USA

Themed Discussion: Heart Failure: Hiding in Plain Sight

"Readmission Risk for Adults With HIV Hospitalized for Heart Failure or Acute Myocardial Infarction" by Ping Yang The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Themed Discussion: Heart Failure: Hiding in Plain Sight

"Heart Failure Among People With HIV: Prescription of Guideline-Directed Medical Therapy" by Melissa K. Cutshaw Duke University School of Medicine, Durham, NC, USA

Themed Discussion: Heart Failure: Hiding in Plain Sight

"Discussion with Audience Q&A" by

Themed Discussion: HIV Self-Testing: Here and Now

"Session Overview" by Mateo Prochazka World Health Organization, Geneva, Switzerland

Themed Discussion: HIV Self-Testing: Here and Now

"National HIV Self-Test Distribution Program: HIV Testing, Diagnosis and Treatment, 3/2023 - 5/2024" by Patrick S. Sullivan Emory University, Atlanta, GA, USA

Themed Discussion: HIV Self-Testing: Here and Now

"Estimating Need for Annual HIV Testing Met by a Nationwide Mailed HIV Self-Testing Program" by Jen Hecht

Themed Discussion: HIV Self-Testing: Here and Now

"Moderators of a Home-Based Couple Intervention on Couple HIV Testing and Counselling Uptake in Kenya" by Zachary A. Kwena Kenya Medical Research Institute-UCSF Infectious Disease Research Training Program, Kisumu, Kenya

Themed Discussion: HIV Self-Testing: Here and Now

"Discussion with Audience Q&A" by

Themed Discussion: KS and KSHV: New Developments in Diagnosis, Therapy, and Pathogenesis

"Session Overview" by James A. Hoxie University of Pennsylvania, Philadelphia, PA, USA

Themed Discussion: KS and KSHV: New Developments in Diagnosis, Therapy, and Pathogenesis

"Validation of Quantification of Lesional KSHV DNA Content for Diagnosis of Kaposi Sarcoma in Africa" by Aggrey Semeere Infectious Diseases Institute, Kampala, Uganda

Themed Discussion: KS and KSHV: New Developments in Diagnosis, Therapy, and Pathogenesis

"Impact of Low-Dose Intra-Lesional Nivolumab for Kaposi Sarcoma on T-Cell Proliferation and Function" by Chia-Ching Wang University of California San Francisco, San Francisco, CA, USA

Themed Discussion: KS and KSHV: New Developments in Diagnosis, Therapy, and Pathogenesis

"Immunologic Responses to Pomalidomide and Liposomal Doxorubicin for Kaposi Sarcoma Treatment" by Matthew Witterholt National Cancer Institute, Bethesda, MD, USA

Themed Discussion: KS and KSHV: New Developments in Diagnosis, Therapy, and Pathogenesis

"Causes of Death Among Adults With HIV-Associated Kaposi Sarcoma in East Africa in the Treat All Era" by Helen Byakwaga Infectious Disease Institute, Kampala, Uganda

Themed Discussion: KS and KSHV: New Developments in Diagnosis, Therapy, and Pathogenesis

"Genome Evolution of Kaposi Sarcoma-Associated Herpesvirus (KSHV) in PLWH" by Dirk P. Dittmer University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Themed Discussion: KS and KSHV: New Developments in Diagnosis, Therapy, and Pathogenesis

"Discussion with Audience Q&A" by

Themed Discussion: Meeting the Treatment and Prevention Needs of Transgender Women

"Session Overview" by Tonia Poteat Duke University, Durham, NC, USA

Themed Discussion: Meeting the Treatment and Prevention Needs of Transgender Women

"Recent HIV Acquisition Among Transgender Women From Midwest Brazil" by Sylvia L. M. Teixeira Oswaldo Cruz Institute – Fiocruz, Rio de Janeiro, Brazil

Themed Discussion: Meeting the Treatment and Prevention Needs of Transgender Women

"High HIV Burden Among Transgender Women in the State Capital and Rural Towns in Central Brazil" by Bruno Vinícius D. Diniz e Silva Federal University of Goias, Goiânia, Brazil

Themed Discussion: Meeting the Treatment and Prevention Needs of Transgender Women

"Time to Antiretroviral Initiation Among Transgender Women Living With HIV in France (1997-2022)" by Juliette Hemery French National Institute of Health and Medical Research (Inserm), Paris, France

Themed Discussion: Meeting the Treatment and Prevention Needs of Transgender Women

"Discussion with Audience Q&A" by

Themed Discussion: Machine Learning: Gearing Up for the Future

"Scientific Overview of Machine Learning: Gearing Up for the Future" by Julia Marcus Harvard Pilgrim Health Care Institute, Boston, MA, USA

Themed Discussion: Machine Learning: Gearing Up for the Future

"Machine Learning to Predict Persons With HIV at Risk of Falling Out of Care" by Thomas Martin University of California San Diego, La Jolla, CA, USA

Themed Discussion: Machine Learning: Gearing Up for the Future

"Enhanced Language Models for Predicting and Understanding HIV Care Disengagement" by Waverly Wei University of Southern California, Los Angeles, CA, USA

Themed Discussion: Machine Learning: Gearing Up for the Future

"An AI-Powered Preventive Intervention for Stigma and Suicidal Ideation in HIV Self-Management" by Diego S. Villanueva Guzman Research Institute of McGill University Health Centre, Montreal, Canada

Themed Discussion: Machine Learning: Gearing Up for the Future

"Discussion with Audience Q&A" by

Themed Discussion: Natural-Born Killers

"Session Overview" by Galit Alter Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA

Themed Discussion: Natural-Born Killers

"HLA-E Prevents Natural Killer Cell Inhibition of HIV-1 Replication in Peripheral Blood CD4+ T Cells" by Amanda M. Dudek Stanford University, Stanford, CA, USA

Themed Discussion: Natural-Born Killers

"Differential CD8T/NK Cell-Mediated HIV-1 Control After TIGIT or KLRG1 Blockade and ART in hBLT Mice" by Ildefonso Sánchez-Cerrillo Hospital Universitario de La Princesa, Madrid, Spain

Themed Discussion: Natural-Born Killers

"Elucidating the Role of Natural Killer Cells in Antibody Breadth During HIV Infection" by Izumi de los Rios Kobara Stanford University, Stanford, CA, USA

Themed Discussion: Natural-Born Killers

"NF-kappa-B Signaling in Natural Killer Cells Predicts Post-Treatment HIV Control" by Ashley F. George Gladstone Institutes, San Francisco, CA, USA

Themed Discussion: Natural-Born Killers

"RV550: IL-15 Superagonist N-803 With ART in Acute HIV Infection Enhances T and NK Cell Proliferation" by Hiroshi Takata Oregon Health and Science University, Portland, OR, USA

Themed Discussion: Natural-Born Killers

"Discussion with Audience Q&A" by

Themed Discussion: SARS-CoV-2 Persistence and Evolutions

"Session Overview" by Alex Sigal Africa Health Research Institute, Mtubatuba, South Africa

Themed Discussion: SARS-CoV-2 Persistence and Evolutions

"SARS-CoV-2 Intra-Host Evolution During Acute Infection in People With COVID-19" by Agostino Riva University of Milan, Milan, Italy

Themed Discussion: SARS-CoV-2 Persistence and Evolutions

"Evolving of Immune Evasion During a SARS-CoV-2 Chronic Infection: A Pathway to Variants of Concern" by Rui Galao King's College London, London, UK

Themed Discussion: SARS-CoV-2 Persistence and Evolutions

"Genetic Mutation Differences Patterns of SARS-CoV-2 in Immunocompromised Patients Versus Controls" by Karen Zafilaza Assistance Publique – Hôpitaux de Paris, Paris, France

Themed Discussion: SARS-CoV-2 Persistence and Evolutions

"ScRNA-seq of HRSV/SARS-CoV-2 Co-Infection Reveals Unique Cellular Responses and lncRNA Signatures" by Claudia Vanetti University of Milan, Milan, Italy

Themed Discussion: SARS-CoV-2 Persistence and Evolutions

"Prevalence, Spread, and Mutation of SARS-CoV-2 Variants in COVID-19 Testing in Salvador, Brazil" by Anna Carolina Dantas Federal University of Bahia, Salvador, Brazil

Themed Discussion: SARS-CoV-2 Persistence and Evolutions

"Discussion with Audience Q&A" by

Themed Discussion: TB Infection and Prevention: Testing, Treatment, and Strategies

"Session Overview" by Salome Charalambous The Aurum Institute, Johannesburg, South Africa

Themed Discussion: TB Infection and Prevention: Testing, Treatment, and Strategies

"Evaluating the Accuracy of Standard F TB-Feron FIA for TB Infection Diagnosis in Vietnam" by Han Thi Nguyen Karolinska Institute, Stockholm, Sweden

Themed Discussion: TB Infection and Prevention: Testing, Treatment, and Strategies

"Effect of Tuberculosis Preventive Therapy on Mtb-Specific T-Cell Profile in the A5279/BRIEF TB Trial" by Pablo C. Alarcon University of Cincinnati Medical Center, Cincinnati, OH, USA

Themed Discussion: TB Infection and Prevention: Testing, Treatment, and Strategies

"The Impact of Rifampin Drug Interactions on TPT Completion and Safety Using High-Dose vs Standard" by Jinell White Alberta Health Services, Calgary, Canada

Themed Discussion: TB Infection and Prevention: Testing, Treatment, and Strategies

"Patient and Provider Preferences for Long-Acting Tuberculosis Preventive Therapy" by Marcia C. Vermeulen University of Cape Town, Cape Town, South Africa

Themed Discussion: TB Infection and Prevention: Testing, Treatment, and Strategies

"Weekly Rifapentine and Isoniazid (3HP) vs Isoniazid Preventive Therapy (6H) Among People With HIV" by Dickens Onyango Kisumu County Department of Medical Services, Public Health, and Sanitation, Kisumu, Kenya

Themed Discussion: TB Infection and Prevention: Testing, Treatment, and Strategies

"Discussion with Audience Q&A" by

Themed Discussion: "Growing Up" With HIV Exposure

"Session Overview" by Ceri Evans University of Liverpool, Liverpool, United Kingdom

Themed Discussion: "Growing Up" With HIV Exposure

"Growth Faltering Is Partially Ameliorated by Infant Gut Bifidobacterium in Children Exposed to HIV" by Nicole Tobin University of California Los Angeles, Los Angeles, CA, USA

Themed Discussion: "Growing Up" With HIV Exposure

"Insulin-Like Growth Factors and Stunting in African Infants Exposed to HIV and Uninfected" by Brenda C. Kakayi Makerere University–Johns Hopkins University Research Collaboration, Kampala, Uganda

Themed Discussion: "Growing Up" With HIV Exposure

"Cardiometabolic Outcomes in HEU vs HU Children in a SA Birth Cohort: Influence of Maternal Lipids" by Calli Dogon Brown University, Providence, RI, USA

Themed Discussion: "Growing Up" With HIV Exposure

"Obesity and Metabolic Comorbidities in Young Adults With Perinatal HIV Exposure Without Infection" by Nikhita Chahal Massachusetts General Hospital, Boston, MA, USA

Themed Discussion: "Growing Up" With HIV Exposure

"Discussion with Audience Q&A" by

Themed Discussion: Hide and Seek: HIV in Tissues

"Session Overview" by Zabrina L. Brumme Simon Fraser University, Burnaby, Canada

Themed Discussion: Hide and Seek: HIV in Tissues

"HIV Reservoir in Jejunum Exhibit Distinct Phenotypic Features and Evoke Innate Cell Redistribution" by Marta Calvet-Mirabent Gladstone Institute, San Francisco, CA, USA

Themed Discussion: Hide and Seek: HIV in Tissues

"Predominance of Non-T Follicular Helper Cell Subsets in the Lymph Node Viral Reservoir During ART" by Vincent H. Wu University of Pennsylvania, Philadelphia, PA, USA

Themed Discussion: Hide and Seek: HIV in Tissues

"HIV Transcriptional Regulation in the CNS of ART-Suppressed People With HIV" by Janna Jamal Eddine RMIT University, Melbourne, Australia

Themed Discussion: Hide and Seek: HIV in Tissues

"Association of CSF Viral Compartmentalization and Macrophage Tropism With Neurosymptomatic HIV" by Laura P. Kincer University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Themed Discussion: Hide and Seek: HIV in Tissues

"Discussion with Audience Q&A" by

Themed Discussion: Lessons in DoxyPEP Implementation

"Session Overview" by Jennifer E. Balkus Public Health–Seattle & King County, Seattle, WA, USA

Themed Discussion: Lessons in DoxyPEP Implementation

"Post-Exposure Prophylaxis With Doxycycline (Doxy PEP) in a Cohort of High-Risk MSM: The PRIDOX Study" by Cristina Gómez-Ayerbe Hospital Universitario Virgen de la Victoria, Málaga, Spain

Themed Discussion: Lessons in DoxyPEP Implementation

"The Actual Need for DoxyPEP Might Not Be as Large as Expected" by Roberto Rossotti ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy

Themed Discussion: Lessons in DoxyPEP Implementation

"Antimicrobial Consumption Among Users of Doxycycline Post-Exposure Prophylaxis in Milan, Italy" by Angelo Roberto Raccagni San Raffaele Vita-Salute University, Milan, Italy

Themed Discussion: Lessons in DoxyPEP Implementation

"DoxyPrEP Impact on the Microbiome of Men Who Have Sex With Men and Transgender Women on HIV PrEP" by Troy Grennan BC Centre for Disease Control, Vancouver, Canada

Themed Discussion: Lessons in DoxyPEP Implementation

"Discussion with Audience Q&A" by

Themed Discussion: Long COVID: Pathogenesis and Clinical Manifestations

"Session Overview" by

Themed Discussion: Long COVID: Pathogenesis and Clinical Manifestations

"Long COVID Associates With Slow Viral Clearance and Viral Rebound During Acute SARS-CoV-2 Infection" by Annukka Antar The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Themed Discussion: Long COVID: Pathogenesis and Clinical Manifestations

"Longitudinal Changes in Arterial Stiffness and Inflammation From Pre- to Post-COVID-19 Infection" by Jhony Baissary Case Western Reserve University, Cleveland, OH, USA

Themed Discussion: Long COVID: Pathogenesis and Clinical Manifestations

"Preserved Adrenal Function in People With Long COVID" by Elizabeth Pasetes The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Themed Discussion: Long COVID: Pathogenesis and Clinical Manifestations

"Plasma Biomarkers in Children and Young People With Long COVID" by Jon Izquierdo-Pujol IrsiCaixa, Badalona, Spain

Themed Discussion: Long COVID: Pathogenesis and Clinical Manifestations

"Immune Profile of Children With Post-COVID-19 Cardiac Contractility Alterations: A Prospective Study" by Costanza Di Chiara University of Padova, Padova, Italy

Themed Discussion: Long COVID: Pathogenesis and Clinical Manifestations

"Discussion with Audience Q&A" by